Hernando de Talavera (1428 - 14 May 1507) was a prominent political and religious figure in Spain during the period of the country's unification and explusion of Muslim rule. He was Queen Isabella I of Castile's confessor, and eventually rose to the office of Archbishop of Granada. He appears to have been descended from Jewish converts, a fact which was used against him in his twilight years by rivals in the Spanish Inquisition. He was imprisoned in 1505, the year following Isabella's death, until Pope Julius II ordered his release. He died in 1507.