Barnesville is an unincorporated community in Rush and Ryan Townships of Schuylkill County, Pennsylvania, United States. Located in the northeastern part of the state, Barnesville lies within the anthracite coal region. Residents who live in Rush Township may attend either Tamaqua Area School District or Mahanoy Area School District, while Ryan Township residents attend Mahanoy Area School District. Barnesville includes Hosensock, Grier City, and Locust Valley. The ZIP code is 18214. The community is in Area code 570 served by the 467 exchange.