In Blood Omen 2, Marcus is encountered in a Boss Battle. The Boss fight takes place in Meridian Cathedral, when Kain is finally able to enter the building at the end of Chapter 4:The Upper City. Unlike fellow 'traitor vampire' Faustus, Marcus made himself known to Kain early in the level and much of Chapter 4: The Upper City ended up being a race between Marcus and Kain to reach the Bishop of Meridian (at the Bishop's Manor and Meridian Cathedral respectively).