First seen during the 1930s in a supporting role in Hatlo's popular gag panel, They'll Do It Every Time, Little Iodine was the daughter of Henry Tremblechin and his wife, Cora. Her purpose was to serve as a pesky nuisance to the strip's star, Henry, and her behavior caused endless misery for her mild-mannered, easily unsettled father. Al Scaduto also contributed to the strip in 1966, with Hy Eisman and Bob Dunn taking the strip from 1967 through its end in 1985. Iodine also appeared in a series of 56 Dell Comics between 1949 and 1962.