Frank Cali was born in New York City in 1965 to Augusto and Agata Cesare, both natives of Palermo, Sicily. His father ran a household goods store in Palermo and a video store in Bensonhurst, Brooklyn. He had a clean police record in the United States, even though he was mentioned in the Pizza Connection investigation, when police discovered that he was a partner of Domenico Adamita, allied to Sicilian Mafia boss Gaetano Badalamenti.