The 2006 Missouri Tigers football team represented the University of Missouri during the 2006 NCAA Division I FBS football season. The Tigers went 8-5, including a 4-4 record in Big 12 North play. The season ended with a 39-38 loss in the Sun Bowl to Oregon State at El Paso. They played their home games at Faurot Field in Columbia, Missouri, and was coached by head coach Gary Pinkel.