Houlihan is known for her role as Molly Witherspoon in the NBC series, Our House starring Wilford Brimley, Deidre Hall, Shannen Doherty and Chad Allen. She starred as J.J. Rutherford in The New Leave it To Beaver from 1984 to 1987. Keri Houlihan was the voice of Molly in the My Little Pony cartoon series and 1986 movie. She guest-starred on television shows including Who's The Boss?, Night Court, I Had Three Wives, V, Gimme a Break, The Jeffersons, Webster, Simon & Simon and Quincy, M.E.