In late 2371, the Serrola served as a flagship for the combined Tal Shiar/Obsidian Order invasion fleet which entered the Gamma Quadrant and launched an attack on the Founders' homeworld in the Omarion Nebula. Upon reaching the planet, the Serrola led the orbital bombardment, but soon discovered that the Founders' had left the planet, and the entire mission was a Dominion ambush. After a failed attempt to escape the nebula, the Serrola tried to battle the vast force of Jem'Hadar attack fighters, but was unable to do so, and was eventually destroyed. (DS9 episode: "The Die is Cast")