USS Preble (DLG-15/DDG-46) was a destroyer in the United States Naval Service. She was the fifth ship named to honor after Commodore Edward Preble (1761–1807). Preble was laid down by Bath Iron Works, Bath, Maine, 16 December 1957. She was launched 23 May 1959 and sponsored by Mrs. Ralph E. Wilson. Preble was commissioned in the Boston Naval Shipyard 9 May 1960, Commander Edward G. Fitz-Patrick in command. She was decommissioned 15 November 1991 and struck 20 November 1992 to be scrapped.