As of the year 2310, the Hermes was under the command of Captain Nyota Uhura. That year, the vessel transported Doctor Carol Marcus to the planet Pacifica in order to test an experimental new Genesis Device. (TOS short story: "The Hero of My Own Life") In 2368, the Hermes took part in Federation blockade of Romulan Star Empire space during the Klingon Civil War. (TNG episode: "Redemption")