In the Cosmic Era, Type S2 influenza is a mutation of the known Type S influenza which caused existing vaccines to become useless, unleashing a outbreak. Rumours begin to spread suggesting Coordinators created this virus to exterminate the Naturals to avenge the late George Glenn. However, religious authorities claim the Type S2 influenza outbreak is a divine punishment, turning public opinion against genetic modification once again which results in the practice being prohibited anywhere on Earth.