German submarine U-376 was a Type VIIC U-boat of the Nazi German Kriegsmarine during World War II. The submarine was laid down in April 1940 in Kiel, launched in July 1941, and commissioned in August 1941 under the command of Oberleutnant zur See Friedrich-Karl Marks. U-376 was attached to the 6th U-boat Flotilla, and was ready for front-line service from 1 March 1942. Operating from Norwegian bases, from July 1942 she served with the 11th U-boat Flotilla, and was transferred to the 3rd U-boat Flotilla, based in France, in early 1943.