SS Mission Santa Clara was a Type T2-SE-A2 tanker built for the United States Maritime Commission during World War II. After the war she was acquired by the United States Navy as USS Mission Santa Clara (AO-132). Later the tanker transferred to the Military Sea Transportation Service as USNS Mission Santa Clara (T-AO-132). She was a member of the Mission Buenaventura-class oiler and was named for Mission Santa Clara de Asís in Santa Clara, California.