Brain is the name given to a DC comics supervillain, a mad scientist of French descent who was robbed of his humanity by the actions of Dr. Niles Caulder who would grow to become "Chief" the leader of Doom Patrol: as a result Brain and his henchmen turned lover, Monsieur Mallah, swore vengeance upon not only "Chief" but the entire Doom Patrol as well as any other hero that crossed their path. As well as appearing in the comic books Brain has appeared as a major antagonist in the Teen Titans cartoon - though much of his backstory (including his relationship with Mallah) was not expanded upon.
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