Mouse Man made his debut as a member of the Academy of Arch-Villains, attacking Wonder Woman after she was blinded by the Fireworks Man. Using his height to his advantage, along with his swiftness, he was able to prove quite a nuisance for Wonder Woman, and at one point injured Steve Trevor during a car accident. Wonder Woman feigned surrender, and Mouse Man led the heroine back to the Academy, where she defeated and imprisoned the criminals. Mouse Man was placed in a bird cage, as his size would allow him to escape from a normal prison.