Salviana State Route 649 begins at the Salviana Turnpike (Highway 426) in Logg County. The route runs north along a two-lane road toward the town of Louisburgh (population 4,996). The route passes on the east side of Louisburgh, and turns northwest toward the small city of Dunncans (population 10,004). About midway between the two communities, Highway 649 intersects Highway 362. The route turns northeast at Dunncans, and continues toward its north end at Dragoonasag Interstate Route 92 about a half mile after crossing into Brennazo County.