Dryfield, Nevada is the setting for most of Parasite Eve II. Aya Brea finds herself in this little town in the Mojave Desert. Here she meets Gary Douglas, the only living resident left in Dryfield, and his dog Flint; who she proceeds to help and befriend. After several chains of events she saves Kyle Madigan on a water tower, and they journey underground into a mine. The people responsible for the recent monsters and attacks have built an underground laboratory near Dryfield and have extensive knowledge on Aya herself. The more extras completed, the more Aya finds out about the secret base.