Contact with Joker Venom causes uncontrollable spasms of laughter, followed by a painful death. The venom hyperstimulates the laughter functions of the brain, leaving the victim unable to breathe. The drug also contains the tetnus toxoid responsible for lock jaw and victims often exhibit a grotesque grinning expression due to spasms of the facial muscles. Sometimes even, victim can gain bulging eyes, paleness, yellowed teeth, etc. similar to the features of the Joker himself.