He was born in Naples to an illustrious house, prominent in the military and administrative service of the House of Aragon. His father Francesco was lord of Torre del Greco, Portici and Resina. His mother, as contemporaries often pointed out, was distantly related to Thomas Aquinas.Though he was elevated to the Archbishopric of Naples (18 November 1458) at a young age, his career was mainly that of a statesman rather than an ecclesiastic. He retained the powerful and lucrative position until September 20, 1484, but kept control of the see at the heart of the Regno by ceding the position to his brother Alessandro, retaining his right to resume it should his brother die, by a papal brief. When that eventuality happened (July 1503), he was archbishop once more, ceding the title to his nephew