The film opens with a vampire (Colin Farrell) systematically stalking and killing an entire family in a suburb of Las Vegas, Nevada. The film then focuses on Charley Brewster (Anton Yelchin), a teenager who discovers that a new neighbor has moved in next door to him. Charley is an average teen, who has recently been accepted as one of the 'cool' kids after a nerdy adolescence. Upon arriving at school, Charley's former friend, "Evil" Ed Lee (Christopher Mintz-Plasse), informs him that many fellow students have gone missing. Charley disregards this, but Ed blackmails him into coming to an old friend's house, the same house seen at the beginning, to check if he is alright.