Vincenzo was born to Domenica and Giacomo Luppino in Calabria, Italy, in 1926. He was the oldest of 10 children. In the early 1950's the family left Italy and headed for Canada. In 1963 Vincenzo married Maria Paiano with whom he had 2 daughters. While living in Canada Vincenzo's father became associated with Buffalo boss Stefano Magaddino and Hamilton leader Johnny "pops" Papalia also known as "The Enforcer". The Luppino family also stretched it's arm to Montreal where Vincenzo's sister Grazia married Paolo Violi.