The 1978 Missouri Tigers football team represented the University of Missouri during the 1978 NCAA Division I-A football season as a member of the Big Eight Conference (Big 8). The team was led by head coach Warren Powers, in his first year, and they played their home games at Faurot Field in Columbia, Missouri. They finished the season with a record of eight wins and four losses (8–4, 4–3 Big 8) and with a victory over LSU in the Liberty Bowl.