The series concentrates on the adventures of the Saturdays, a family of cryptozoologists who work to keep the truth about cryptids from getting out in order to protect both the human race and the creatures themselves. The Saturdays travel the world searching for cryptids to study and battling twisted villains like the megalomaniac V.V. Argost. The series is influenced by the style of 1960s-era Hanna-Barbara action series (such as Jonny Quest), and is combined with creator Jay Stephens's own personal interest in cryptozoology.