Tsukune is an ordinary human, who accidentally enrolled at Yōkai Academy, a school for monsters hidden away from the human world by a large barrier. He meets Moka Akashiya, who accidentally bumps her bicycle to him. At first sight, Tsukune falls in love with Moka and notes that she is the cutest girl he has ever seen in his entire life. Moka then sucks some of his blood and notes that it is the most delicious blood she has tasted. Moka reveals to him that she is a vampire and the two instantly become friends.