Smilodon Fang is a solo mission you can take after the Crocogator mission with Jarvis. It is one of three jobs you can take right after the Crocogator mission, the other two being A Masterpiece of Fantasy and Beasts by the Bridge. Once you pick the request up from Thanos, you head for the Olacion Order to speak with Dwight. After a cutscene you head out towards the Ocho Region.