Their inital appearance saw them originate from some point in the far future, but had also been temporarily living in both the Permian era and the present day. In the second timeline Future Predators were apparently not natural creatures and were created in the ARC because of something Christine Johnson would apparently come to do after taking over the ARC, implying they were genetic mutants, created using cloning mechanisms. It is also possible that they were cloned from their future selves' DNA, creating a time paradox.