Salisbury is a city in southeastern Maryland, United States. It is the county seat of Wicomico County, Maryland and the largest city in Maryland's Eastern Shore region. The city's population was 30,343 at the 2010 census. Salisbury is the principal city of the Salisbury, Maryland Metropolitan Statistical Area, which is part of the Salisbury-Ocean Pines, Maryland Combined Statistical Area. The city is the commercial hub of the Delmarva Peninsula and is sometimes called "the Crossroads of Delmarva".