Louie/Louise was a resident of the building and the inhabitant of apartment 4B before Penny. He was originally mentioned in the pilot episode, being described as a "200 pound transvestite with a skin condition". He was mentioned again in the second episode of the series, "The Big Bran Hypothesis". Sheldon states that Louie/Louise's closet was "immaculate", keeping his dress}es, cocktail gowns and police uniforms in order. Sheldon had helped him install a webcam in his bedroom.