The play began life as a short radio play broadcast on 30 May 1947 called Three Blind Mice in honour of Queen Mary, the consort of King George V. The play had its origins in the real-life case of the death of a boy, Dennis O'Neill, who died while in the foster care of a Shropshire farmer and his wife in 1945. The play's longevity has ensured its popularity with tourists from around the world, and in 1997, with producer Stephen Waley-Cohen, it helped spawn a theatrical education charity, Mousetrap Theatre Projects, which helps young people experience London's theatre.
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