It was released when Guybrush Threepwood stabbed LeChuck with a faulty Cursed Cutlass of Kaflu which had been made using inferior ingredients. When the cutlass hit LeChuck, it was meant to destroy the demon forever, but instead it sucked out his voodoo essence, sending some into Threepwood's hand and the rest into the air to infect the nearby population. The effects of the pox caused its victims to become more aggressive and uncontrollable, even lashing out at those close to them. It occured in various stages that seemed to affect some faster than others: