Dopamine Reuptake Inhibitors or Dopamine Uptake Inhibitors are compounds that inhibit the reuptake of the neurotransmitter dopamine after it is released and used at the synapse. I In so doing, DRIs tend to increase the amount of dopamine present in the brain, which increases feelings of enjoyment and motivation. Other drugs which impact the level of dopamine in the brain include bupropion (Wellbutrin, Zyban), sertraline (Zoloft) (at high doses), Benztropine, Nomifensine, Mazindol, and a new class of reuptake inhibitors, the GBR Series.