Wendy was adopted as a 3 month old shelter kitty and developed diabetes at age 10, about a year after our first diabetic cat, Casey, died from chronic renal failure at age 19. We started with Blue Ridge PZI insulin and she did well on bid dosing, in a multi-cat household. Over time she seemed to require higher doses, so we tried a slightly different insulin and had better results. This happened several times over the past few years, and we would change again.