Wes is the nephew of Dr. Katherine Pulaski, but in defiance of the family's medical traditions Wes chose to follow a different branch of sciences, preferring warp plasma over blood plasma. Wes graduated with honours from Starfleet Academy and initially worked at Starfleet Command, developing new weapons and defensive systems for starships, until he was recruited by Captain Marcus Refelian to join the crew of the USS Incursion. (TNG video game: Away Team)