The primary symptom of the sickness is the Cruxis Crystal causes the victim's skin to crystallize, eventually leading to death when their internal organs freeze. At the time of her sickness, Colette believes she is going to become "one big Exsphere". Another symptom may involve mana drain, as Colette often collapses in pain after being brought back from her soulless state. Although the specific reason for Colette's rejection of her Cruxis Crystal is unknown, she may have contracted the sickness because of the lack of a Key Crest, which Lloyd Irving eventually gives her. Another possibility is directed toward her mana signature being the same as Martel's, the only other known individual to contract the sickness.