German submarine U-133 was a Type VIIC U-boat built for the Nazi German Kriegsmarine for service during World War II. She was laid down on 10 August 1940 by Vegesacker Werft, Bremen-Vegesack as Werk 12, launched on 28 April 1941 and commissioned on 5 July that year. U-133 sank after striking a mine, probably a German one, off Salamis Island on 14 March 1942. All hands were lost in the event.