The West Indies Squadron, or the West Indies Station, was a United States Navy squadron that operated in the West Indies in the early nineteenth century. It was formed due to the need to suppress piracy in the Caribbean Sea, the Antilles and the Gulf of Mexico region of the Atlantic Ocean. This unit later engaged in the Second Seminole War until being combined with the Home Squadron in 1842. From 1822 to 1826 the squadron was based out of Saint Thomas Island until the Pensacola Naval Yard was constructed.