Ofonius Tigellinus, also known as Ophonius Tigellinus and Sophonius Tigellinus (c. 10–69), was a prefect of the Roman imperial bodyguard, known as the Praetorian Guard, from 62 until 68, during the reign of emperor Nero. Tigellinus gained imperial favour through his acquaintance with Nero's mother Agrippina the Younger, and was appointed prefect upon the death of his predecessor Sextus Afranius Burrus, a position Tigellinus held first with Faenius Rufus and then Nymphidius Sabinus.