The Terrorweb Queen spawns together with four Obsidian Guardians in a small passageway. The Guardians use Wards to defend themselves and the Queen against anyone who comes near. In addition, their regular attacks knockdown foes sometimes. However, you can easily use spells that do not require a line of sight to target them, and kill them one by one, from behind a wall. Note that the Guardians use Obsidian Flesh. Look for it and wait for it to wear off, interrupt it or remove it using non-spell or non-targeted enchantment removers. After killing two Guardians on one side, you can teleport to a Reaper on the other side, to attack the other two in the same manner.