USS Mississinewa (AO-59) was the first of two United States Navy ships of the name. She was a T3-S2-A3 Auxiliary Oiler of the US Navy, laid down on 5 October 1943 by the Bethlehem Sparrows Point Shipyard, Inc., Sparrows Point, Maryland; launched on 28 March 1944; sponsored by Miss Margaret Pence; and commissioned on 18 May 1944. Mississinewa was commanded by Captain Philip G. Beck.