USS SC-48, sometimes styled as either Submarine Chaser No. 48 or S.C.-48, was an SC-1-class submarine chaser built for the United States Navy during World War I. Like most members of her class, she was not named and known only by her designation. SC-48 was built at New York Navy Yard in Brooklyn, New York in 1918. She was commissioned 27 March 1918. It is unclear if SC-48 remained in commission on 17 July 1920. If she were, she would have received, as part of the new U.S. Navy letter-number scheme, the hull designation of PC-48.