was an empress of the Ōtsutsuki Clan most known for her theft of the Tailed Beast, Kurama around the time of Hagoromo Ōtsutsuki's departure, making her remembered as the . Due to Kurama's instability, Karehime was given an ability which allowed her to freely manipulate the cells of her body, which would later be passed down to her own descendants, Sakon and Ukon. She died soon after the birth of her children due to Kurama breaking free of her control.