40 CR.25s were ordered after the operative failure of the apparently more promising Breda Ba.88 bomber. Later, it was decided to use the CR.25 as a reconnaissance plane, with a total of 10 aircraft entering service. It was used during the war by the 173a Squadriglia Ricognizione Strategica Terrestre (Strategic Land Reconnaissance Squadron), operating from Sicily. Despite the positive reports from the pilots, and a proposal by Fiat to resume production, no further aircraft were produced. It was also used for transport of senior air force officers from Rome to Berlin.