Abbott and Costello Meet Frankenstein opens with an anxious man (Lon Chaney, Jr.) placing a call from London to a Florida freight-handling branch of a railway station. A freight-handling employee, Wilbur (Lou Costello), answers the call and is warned not to open the two crates addressed to “McDougal’s House of Horrors” until the London man makes his arrival at the station. This conversation abruptly ends when the London man turns into a werewolf as a full moon rises.