HMS Enterprize, also known as HMS Enterprise, was an 8-gun sloop of the Royal Navy. The Enterprize was a barca-longa captured from the Spanish in 1743, and re-rated as a sloop. She spent her entire career in the Mediterranean as a despatch vessel and tender, being commissioned in 1743 under Lieutenant Thomas Herring. She was present at the Battle of Toulon in 1744, and was then paid off in 1745.