Charlie McGee is still on the run from the secret government agency known as The Shop, who want to take her pyrokinesis (ability to start fires with her mind) and use it for the military. Her archnemesis John Rainbird has survived and is helping The Shop again. They are on the way to their final confrontation. Charlie gets help from James Richardson (Dennis Hopper), one of the victims of the LOT-6 experiment. The experiment has given James the ability to tell the future. When Vincent discovers that he's been duped into luring Charlie back to Rainbird, Vincent also decides to help Charlie.