In "I Never Met the Dead Man" he appears riding in a car with Peter Griffin, they run over the Road Runner. When Peter realizes it, he tells him that Road Runner is fine & to keep going. In "PTV" he appears in a cutaway when Peter claims he worked for ACME. He offers a store credit when Wile E. claims a refund for a giant sling shot that slammed him into a mountain. Mrs. Coyote then appears telling her husband to hurry up. Wile E. was voiced by Seth MacFarlane.