On top of Oscorp Tower, the Lizard and Spider-Man get into a fight. Lizard then chokes Spider-Man until Captain George Stacy arrives and shoots the Lizard multiple times, buying Spider-Man time to get free and retrieve the cure to Connors' mutagen from Stacy. The Lizard recovers and fatally wounds Stacy. He then attempts to stop Spider-Man stopping the Ganali device from unleashing his lizard formula but fails as Peter loads the antidote into the machine. Once exposed to the antidote, the Lizard transforms back into Connors, who saves Peter from falling off the building.