In the game, a sorceress named Annette (or alternately Annet) who is descended by blood from the god, Hastur, must use her supernatural powers to prevent the Hastur Group from summoning Hastur to New York City. In this she is opposed by the members of the Hastur Group, including it's Bishop, Henry, and another sorceress descended from Hastur's accursed bloodline name Restiana. Besides these threats, the gangster, Vincent De Marco, is working with the Hastur Group for his own purposes.