Tretonin is a substance originally created by the Pangarans around the year 1970 to replicate the effects of perfect health imparted by a Goa'uld symbiote in the form of a drug for use in humans. The drug was created in a process which utilized the prim'ta of a Goa'uld Queen. When injected into humans, in its original form, the drug suppresses the natural human immune system and requires daily injections. It was later refined by the Tok'ra to replace the need for a symbiote exclusively in Jaffa.