The episode opens with two subway repairmen in conversation. They are then attacked by an over-sized lizard and one of them is kidnapped. Thus, Daily Bugle reports show mysterious disappearances throughout Manhattan and rumors of a giant lizard. Publisher J. Jonah Jameson (Edward Asner) subsequently offers a $1000 bonus to any photographer who can capture an image of the beast. Reporter Peter Parker (Christopher Daniel Barnes), despite originally considering the lizard rumors to be a hoax, plans to claim the reward in order to help pay off some of his Aunt May (Linda Gary)'s large debts. Peter subsequently makes his way to interview his science professor, Dr. Curt Connors (Joseph Campanella), a scientist in which works with reptiles. While paying him a visit, he and fellow science student